عوامل التخثر والمواد المتعلقة
رقم أو اسم عامل التخثر |
الوضيفة |
I (فيبرينوجين) |
Forms clot (fibrin) |
II (بروثرومبين) |
Its active form (IIa) activates I, V, VII, XIII, protein C, platelets |
Tissue factor |
Co-factor of VIIa (formerly known as factor III) |
كالسيوم |
Required for coagulation factors to bind to phospholipid (formerly known as factor IV) |
V (proaccelerin, labile factor) |
Co-factor of X with which it forms the prothrombinase complex |
VI |
Unassigned – old name of Factor Va |
VII (stable factor) |
Activates IX, X |
VIII (antihemophilic factor) |
Co-factor of IX with which it forms the tenase complex |
IX (Christmas factor) |
Activates X: forms tenase complex with factor VIII |
X (Stuart-Prower factor) |
Activates II: froms prothrombinase complex with factor V |
XI (plasma thromboplastin antecedent) |
Activates XII, IX and prekallikrein |
XII (Hageman factor) |
Activates prekallikrein and fibrinolysis |
XIII (fibrin-stabilizing factor) |
Crosslinks fibrin |
عامل فون ويليبراند |
Binds to VIII, mediates platelet adhesion |
prekallikrein |
Activates XII and prekallikrein; cleaves HMWK |
high molecular weight kininogen (HMWK) |
Supports reciprocal activation of XII, XI, and prekallikrein |
فايبرونيكتين |
Mediates cell adhesion |
ضد الثرومبين III |
Inhibits IIa, Xa, and other proteases; |
heparin cofactor II |
Inhibits IIa, cofactor for heparin and dermatan sulfate ("minor antithrombin") |
بروتين C |
Inactivates Va and VIIIa |
بروتين S |
Cofactor for activated protein C (APC, inactive when bound to C4b-binding protein) |
بروتين Z |
Mediates thrombin adhesion to phospholipids and stimulates degradation of factor X by ZPI |
Protein Z-related protease inhibitor (ZPI) |
Degrades factors X (in presence of protein Z) and XI (independently) |
plasminogen |
Converts to plasmin, lyses fibrin and other proteins |
alpha 2-antiplasmin |
Inhibits plasmin |
tissue plasminogen activator (tPA) |
Activates plasminogen |
urokinase |
Activates plasminogen |
plasminogen activator inhibitor-1 (PAI1) |
Inactivates tPA & urokinase (endothelial PAI) |
plasminogen activator inhibitor-2 (PAI2) |
Inactivates tPA & urokinase (placental PAI) |
cancer procoagulant |
Pathological factor X activator linked to thrombosis in cancer |